AKT1
About
Location: 14q32.33
Mappings
Biomarkers
AKT1 is involved in the following curated biomarkers.
| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| AKT1 amplification | Copy Number | 3 | 4 |
| AKT1 somatic variants | Somatic Variant | 3 | 4 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.
| Organization(s) | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| EMA (1) FDA (1) | AKT1 amplification, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (1) | AKT1 amplification, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (1) | AKT1 amplification, ER positive, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| EMA (1) FDA (1) | AKT1 somatic variants, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (1) | AKT1 somatic variants, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (1) | AKT1 somatic variants, ER positive, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant |