Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that Wild type ALK, Wild type EGFR status confers therapeutic sensitivity to Carboplatin, Pembrolizumab, Pemetrexed in patients with Non-Small Cell Lung Cancer.

This statement is based on a regulatory approval from the Health Service Executive:

Pembrolizumab is indicated in combination with PEMEtrexed and CARBOplatin for the first-line treatment of metastatic non-squamous NSCLC in adults whose tumors have no EGFR or ALK positive mutations

Citation

Pembrolizumab, PEMEtrexed and CARBOplatin (AUC 5) Therapy, 2022, version number 4, NCCP National SACT Regimen, NCCP, viewed 04/04/2024, https://www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/lung/568.pdf