Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that Wild type ALK, Wild type EGFR status confers therapeutic sensitivity to Cisplatin, Pembrolizumab, Pemetrexed in patients with Non-Small Cell Lung Cancer.

This statement is based on a regulatory approval from the Health Service Executive:

Pembrolizumab is indicated in combination with PEMEtrexed and CISplatin for the first-line treatment of metastatic non-squamous NSCLC in adults whose tumors have no EGFR or ALK positive mutations

Citation

Pembrolizumab, PEMEtrexed and CISplatin Therapy, 2022, version number 4, NCCP National SACT Regimen, NCCP, viewed 04/04/2024, https://www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/lung/569.pdf