Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that PML::RARA status confers therapeutic sensitivity to Arsenic trioxide in patients with APL with PML-RARA.

This statement is based on a regulatory approval from the Health Service Executive:

Treatement of patients with newly diagnosed low to intermediate risk Acute Promyelocytic Leukaemia (APL) (defined as WCC count <= 10x10^9/L)

Citation

Trentinoin (ATRA) and Arsenic Trioxide (ATO) Induction Therapy, 2023, version number 4, NCCP National SACT Regimen, NCCP, viewed 01/09/2024, https://www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/leukemia-bmt/356-tretinoin-atra-with-arsenic-trioxide-ato-induction-therapy.pdf