Therapies

Therapies are the individual cancer treatments referenced by propositions in the database. Each therapy has a therapy type defined by the National Cancer Institute: chemotherapy, hormone therapy, immunotherapy, or targeted therapy. The proposition and statement counts include those where the therapy is given as part of a combination.

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Therapy types
Therapy strategies
Name Therapy strategies Therapy type Propositions Statements
Abemaciclib CDK4/6 inhibition Targeted therapy 19 61
Abiraterone acetate Antiandrogen Hormone therapy 17 31
Acalabrutinib BTK inhibition Targeted therapy 3 3
Adagrasib RAS inhibition Targeted therapy 2 3
Afatinib EGFR inhibition Targeted therapy 2 3
Alectinib ALK inhibition Targeted therapy 1 7
Alpelisib PI3K/AKT/mTOR inhibition Targeted therapy 3 6
Amivantamab EGFR inhibition Targeted therapy 6 18
Anastrozole Aromatase inhibition Hormone therapy 22 52
Arsenic trioxide PML::RARA inhibition Targeted therapy 2 7
Asciminib BCR-ABL inhibition Targeted therapy 2 6
Atezolizumab PD-1/PD-L1 inhibition Immunotherapy 18 38
Aumolertinib EGFR inhibition Targeted therapy 3 3
Avapritinib KIT inhibition Targeted therapy 1 2
Avutometinib MEK inhibition, RAF inhibition Targeted therapy 2 2
Azacitidine Hypomethylating agent chemotherapy Chemotherapy 5 10
Belzutifan HIF-2a inhibition Targeted therapy 3 6
Bendamustine Alkylating chemotherapy Chemotherapy 2 3
Bevacizumab VEGF inhibition Targeted therapy 28 63
Binimetinib MEK inhibition Targeted therapy 3 14
Blinatumomab CD19 inhibition Immunotherapy 3 13
Bosutinib BCR-ABL inhibition Targeted therapy 1 6
Brentuximab vedotin target CD30 antigens Targeted therapy 9 14
Brigatinib ALK inhibition Targeted therapy 1 5
Camizestrant Estrogen receptor inhibition Targeted therapy 3 3
Capecitabine Thymidylate synthase inhibition Chemotherapy 23 32
Capivasertib PI3K/AKT/mTOR inhibition Targeted therapy 23 30
Capmatinib MET inhibition Targeted therapy 2 4
Carboplatin Platinum-based chemotherapy Chemotherapy 50 100
Cemiplimab PD-1/PD-L1 inhibition Immunotherapy 4 4
Ceritinib ALK inhibition Targeted therapy 1 4
Cetuximab EGFR inhibition Targeted therapy 10 15
Chlorambucil Alkylating chemotherapy Chemotherapy 1 1
Cisplatin Platinum-based chemotherapy Chemotherapy 45 64
Cobimetinib MEK inhibition Targeted therapy 4 8
Corticosteroid Anti-inflammatory Hormone therapy 3 3
Crizotinib ALK inhibition, MET inhibition, ROS1 inhibition Targeted therapy 4 10
Cyclophosphamide Alkylating chemotherapy Chemotherapy 30 71
Cytarabine DNA Polymerase inhibition Chemotherapy 19 28
Dabrafenib B-RAF inhibition Targeted therapy 11 40
Dacarbazine Nonclassical alkylating chemotherapy Chemotherapy 2 2
Dacomitinib EGFR inhibition Targeted therapy 3 4
Dasatinib BCR-ABL inhibition Targeted therapy 3 10
Datopotamab deruxtecan Topoisomerase inhibition, Trop-2 directed antibody Targeted therapy 8 8
Daunorubicin Topoisomerase inhibition Chemotherapy 15 21
Defactinib FAK inhibition Targeted therapy 2 2
Dexamethasone Corticosteroid Chemotherapy 5 6
Docetaxel Taxane-based chemotherapy Chemotherapy 11 49
Dordaviprone Protease activation Targeted therapy 2 2
Dostarlimab PD-1/PD-L1 inhibition Immunotherapy 5 8
Doxorubicin Topoisomerase inhibition Chemotherapy 23 50
Durvalumab PD-1/PD-L1 inhibition Immunotherapy 14 27
Elacestrant ER signaling inhibition Hormone therapy 3 6
Enasidenib IDH2 inhibition Targeted therapy 9 9
Encorafenib B-RAF inhibition Targeted therapy 6 22
Ensartinib ALK inhibition Targeted therapy 1 1
Entrectinib ALK inhibition, NTRK inhibition, ROS1 inhibition Targeted therapy 4 12
Enzalutamide Antiandrogen Hormone therapy 24 24
Epirubicin Topoisomerase inhibition Chemotherapy 4 18
Erdafitinib FGFR inhibition Targeted therapy 6 17
Eribulin Tubulin polymerization inhibition Chemotherapy 1 1
Erlotinib EGFR inhibition Targeted therapy 8 11
Etoposide Topoisomerase inhibition Chemotherapy 10 10
Everolimus PI3K/AKT/mTOR inhibition Targeted therapy 7 10
Exemestane Aromatase inhibition Hormone therapy 13 23
Fludarabine Antimetabolite Chemotherapy 2 2
Fluorouracil Thymidylate synthase inhibition Chemotherapy 38 66
Fulvestrant Estrogen receptor inhibition Hormone therapy 47 88
Futibatinib FGFR inhibition Targeted therapy 3 3
Gefitinib EGFR inhibition Targeted therapy 3 3
Gemcitabine Antimetabolite Chemotherapy 10 17
Gemtuzumab ozogamicin CD33 inhibition Immunotherapy 2 4
Gilteritinib FLT3 inhibition Targeted therapy 8 12
Goserelin Gonadotropin-releasing hormone (GnRH) agonist Hormone therapy 6 18
Ibrutinib BTK inhibition Targeted therapy 5 6
Idarubicin Topoisomerase inhibition Chemotherapy 1 3
Idelalisib PI3K/AKT/mTOR inhibition Targeted therapy 3 6
Ifosfamide Alkylating chemotherapy Chemotherapy 1 1
Imatinib Bcr-Abl inhibition, PDGF-R inhibition, c-Kit inhibition Targeted therapy 13 23
Imlunestrant Estrogen receptor inhibition Targeted therapy 1 2
Inavolisib PI3K/AKT/mTOR inhibition Targeted therapy 3 9
Infigratinib FGFR2 inhibition Targeted therapy 1 1
Inotuzumab ozogamicin BCR-ABL inhibition Targeted therapy 2 7
Interferon Alpha Cytokine stimulation Immunotherapy 1 1
Ipilimumab CTLA-4 inhibition Immunotherapy 8 35
Irinotecan Topoisomerase I inhibition Chemotherapy 5 6
Ivosidenib IDH1 inhibition Targeted therapy 20 40
Lapatinib HER2 inhibition Targeted therapy 8 12
Larotrectinib NTRK inhibition Targeted therapy 3 12
Lazertinib EGFR inhibition Targeted therapy 2 10
Lenalidomide Angiogenesis inhibition Chemotherapy 2 2
Lenvatinib VEGFR inhibition Targeted therapy 1 1
Letrozole Aromatase inhibition Hormone therapy 26 72
Lorlatinib ALK inhibition Targeted therapy 1 4
Margetuximab HER2 inhibition Hormone therapy 4 4
Methotrexate Antifolate Chemotherapy 7 8
Midostaurin FLT3 inhibition Targeted therapy 11 14
Mirvetuximab soravtansine Folate receptor-alpha inhibition Chemotherapy 3 6
Mitoxantrone Topoisomerase inhibition Chemotherapy 2 2
Mobocertinib EGFR inhibition Targeted therapy 1 1
Nab-paclitaxel Taxane-based chemotherapy Chemotherapy 6 8
Neratinib HER2 inhibition Targeted therapy 8 14
Nilotinib BCR-ABL inhibition Targeted therapy 1 6
Niraparib PARP inhibition Targeted therapy 14 28
Nivolumab PD-1/PD-L1 inhibition Immunotherapy 29 77
Obinutuzumab CD20 inhibition Targeted therapy 3 4
Olaparib PARP inhibition Targeted therapy 68 166
Olutasidenib IDH1 inhibition Targeted therapy 5 5
Osimertinib EGFR inhibition Targeted therapy 12 25
Oxaliplatin Platinum-based chemotherapy Chemotherapy 28 40
Paclitaxel Taxane-based chemotherapy Chemotherapy 47 100
Palbociclib CDK4/6 inhibition Targeted therapy 26 44
Panitumumab EGFR inhibition Targeted therapy 5 6
Pembrolizumab PD-1/PD-L1 inhibition Immunotherapy 62 106
Pemetrexed Antifolate Chemotherapy 22 46
Pemigatinib FGFR inhibition Targeted therapy 4 4
Pertuzumab HER2 inhibition Targeted therapy 24 72
Ponatinib BCR-ABL inhibition Targeted therapy 5 11
Pralsetinib RET inhibition Targeted therapy 2 2
Prednisolone Corticosteroid Chemotherapy 19 33
Prednisone Corticosteroid Chemotherapy 15 23
Quizartinib FLT3 inhibition Targeted therapy 4 10
Ramucirumab VEGF/VEGFR inhibition Targeted therapy 3 3
Relatlimab LAG-3 inhibition Immunotherapy 1 1
Repotrectinib ROS inhibition Targeted therapy 4 8
Revumenib Menin inhibition Targeted therapy 5 5
Ribociclib CDK4/6 inhibition Targeted therapy 16 46
Rituximab CD20 inhibition Immunotherapy 25 42
Rucaparib PARP inhibition Targeted therapy 16 16
Sacituzumab govitecan Topoisomerase inhibition Targeted therapy 5 11
Selpercatinib RET inhibition Targeted therapy 6 8
Sevabertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Sotorasib RAS inhibition Targeted therapy 1 2
Sunvozertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Talazoparib PARP inhibition Targeted therapy 27 31
Taletrectinib NTRK inhibition, ROS1 inhibition Targeted therapy 1 1
Tamoxifen Estrogen receptor inhibition Hormone therapy 3 9
Tazemetostat EZH2 inhibition Targeted therapy 7 7
Telisotuzumab Vedotin MET inhibition Targeted therapy 1 1
Tepotinib MET inhibition Targeted therapy 2 6
Tislelizumab PD-1/PD-L1 inhibition Immunotherapy 26 28
Tovorafenib B-RAF inhibition Targeted therapy 4 8
Trametinib MEK inhibition Targeted therapy 11 39
Trastuzumab HER2 inhibition Targeted therapy 59 140
Trastuzumab deruxtecan HER2 inhibition Targeted therapy 15 29
Trastuzumab emtansine HER2 inhibition Targeted therapy 1 6
Tremelimumab CTLA-4 inhibition Immunotherapy 6 12
Tucatinib HER2 inhibition Targeted therapy 2 3
Vandetanib RET inhibition Targeted therapy 1 2
Vemurafenib B-RAF inhibition Targeted therapy 8 15
Venetoclax BCL2 inhibition Targeted therapy 5 10
Vepdegestrant Estrogen receptor inhibition Targeted therapy 1 1
Vinblastine Vinca alkaloid chemotherapy Targeted therapy 1 1
Vincristine Vinca alkaloid chemotherapy Chemotherapy 20 28
Vinorelbine Vinca alkaloid chemotherapy Chemotherapy 2 3
Vorasidenib IDH1/2 inhibition Targeted therapy 20 40
Zanidatamab ER signaling inhibition Targeted therapy 3 6
Zanubrutinib BTK inhibition Targeted therapy 3 3
Zenocutuzumab NRG1 inhibition Targeted therapy 3 3
Ziftomenib Menin inhibition Targeted therapy 1 1
Zolbetuximab CLDN18.2 inhibition Immunotherapy 2 4
Zongertinib HER2 inhibition Targeted therapy 1 1