BRCA2 oncogenic variants

About

Gene context: BRCA2

Biomarker Type: Somatic Variant

Present: True

Chromosome: 13

Requires Oncogenic: True


Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisolone
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisone
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Rucaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Rucaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Rucaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Rucaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Enzalutamide, Talazoparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Niraparib, Prednisolone
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Niraparib, Prednisolone
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Olaparib