FGFR3

About

Location: 4p16.3

Mappings

HGNC: HGNC:3690

Ensembl: ENSG00000068078

NCBI: 2261

Refseq: NM_000142.5

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Biomarkers

FGFR3 is involved in the following curated biomarkers.

Name Biomarker type Propositions Statements
FGFR3::TACC3 Rearrangement 1 3
FGFR3::BAIAP2L1 Rearrangement 1 2
FGFR3 p.R248C Somatic Variant 1 3
FGFR3 p.S249C Somatic Variant 1 3
FGFR3 p.G370C Somatic Variant 1 3
FGFR3 p.Y373C Somatic Variant 1 3

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) FGFR3::TACC3 Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3::BAIAP2L1 Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.R248C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.S249C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.G370C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.Y373C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3::TACC3 Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3::BAIAP2L1 Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.R248C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.S249C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.G370C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.Y373C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.R248C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.S249C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.G370C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3 p.Y373C Bladder Urothelial Carcinoma Erdafitinib
Sensitivity (+) FGFR3::TACC3 Bladder Urothelial Carcinoma Erdafitinib