IDH2

About

Location: 15q26.1

Mappings

HGNC: HGNC:5383

Ensembl: NM_002168.4

NCBI: ENSG00000182054

Refseq: 3418

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Biomarkers

IDH2 is involved in the following curated biomarkers.

Name Biomarker type Propositions Statements
IDH2 p.R140Q Somatic Variant 1 1
IDH2 p.R140L Somatic Variant 1 1
IDH2 p.R140G Somatic Variant 1 1
IDH2 p.R140W Somatic Variant 1 1
IDH2 p.R172K Somatic Variant 3 3
IDH2 p.R172M Somatic Variant 3 3
IDH2 p.R172G Somatic Variant 3 3
IDH2 p.R172S Somatic Variant 3 3
IDH2 p.R172W Somatic Variant 3 3

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) IDH2 p.R140Q Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140L Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140G Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R140W Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172K Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172M Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172G Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172S Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172W Acute Myeloid Leukemia Enasidenib
Sensitivity (+) IDH2 p.R172K Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172M Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172G Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172S Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172W Astrocytoma Vorasidenib
Sensitivity (+) IDH2 p.R172K Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172M Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172G Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172S Oligodendroglioma Vorasidenib
Sensitivity (+) IDH2 p.R172W Oligodendroglioma Vorasidenib