ERBB2 amplification

About

Gene context: ERBB2

Biomarker Type: Copy Number

Present: True

Direction: Amplification


Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Docetaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Non-Small Cell Lung Cancer Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Adenocarcinoma of the Gastroesophageal Junction Trastuzumab deruxtecan
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Paclitaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Docetaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Anastrozole, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Paclitaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Docetaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Carboplatin, Docetaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Doxorubicin, Paclitaxel, Trastuzumab
Sensitivity (+) ERBB2 amplification Esophagogastric Adenocarcinoma Capecitabine, Cisplatin, Trastuzumab
Sensitivity (+) ERBB2 amplification Esophagogastric Adenocarcinoma Cisplatin, Fluorouracil, Trastuzumab
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab emtansine
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Trastuzumab emtansine
Sensitivity (+) ER positive, ERBB2 amplification, PR positive Invasive Breast Carcinoma Neratinib
Sensitivity (+) ER positive, ERBB2 amplification Invasive Breast Carcinoma Neratinib
Sensitivity (+) ERBB2 amplification, PR positive Invasive Breast Carcinoma Neratinib
Sensitivity (+) ERBB2 amplification Invasive Breast Carcinoma Capecitabine, Lapatinib
Sensitivity (+) ER positive, ERBB2 amplification, PR negative Invasive Breast Carcinoma Lapatinib, Trastuzumab
Sensitivity (+) ER positive, ERBB2 amplification, PR positive Invasive Breast Carcinoma Lapatinib, Letrozole
Sensitivity (+) ER positive, ERBB2 amplification, PR positive Invasive Breast Carcinoma Neratinib
Sensitivity (+) ER positive, ERBB2 amplification Invasive Breast Carcinoma Neratinib
Sensitivity (+) ERBB2 amplification, PR positive Invasive Breast Carcinoma Neratinib