FLT3

Biomarkers

FLT3 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
FLT3 p.I836del	Somatic Variant	1	1
FLT3 p.I836N	Somatic Variant
FLT3 p.D835Y	Somatic Variant	3	4
FLT3-ITD	Somatic Variant	7	15
FLT3 p.D835A	Somatic Variant	2	2
FLT3 p.D835E	Somatic Variant	2	2
FLT3 p.D835H	Somatic Variant	2	2
FLT3 p.D835N	Somatic Variant	2	2
FLT3 p.D835V	Somatic Variant	2	2
FLT3 p.D835S	Somatic Variant	2	2

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Organization(s)	Biomarker(s)	Cancer type	Therapy(ies)
FDA (1)	FLT3 p.I836del	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835Y	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835Y	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
EMA (1) HSE (1)	FLT3 p.D835Y	Acute Myeloid Leukemia	Gilteritinib
FDA (1)	FLT3-ITD	Acute Lymphoid Leukemia	Gilteritinib
EMA (1) FDA (1) HSE (1)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
EMA (1) HSE (1)	FLT3-ITD	Acute Myeloid Leukemia	Gilteritinib
HSE (2)	FLT3-ITD	Acute Myeloid Leukemia	Midostaurin
EMA (1) FDA (1)	FLT3-ITD	Acute Myeloid Leukemia	Quizartinib
EMA (1) FDA (1) HSE (1)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Quizartinib
EMA (1) FDA (1)	FLT3-ITD	Acute Myeloid Leukemia	Cytarabine, Idarubicin, Quizartinib
FDA (1)	FLT3 p.D835A	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835A	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835E	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835E	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835H	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835H	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835N	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835N	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835V	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835V	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin
FDA (1)	FLT3 p.D835S	Acute Lymphoid Leukemia	Gilteritinib
FDA (1)	FLT3 p.D835S	Acute Myeloid Leukemia	Cytarabine, Daunorubicin, Midostaurin