BCR::ABL1

About

Gene context: ABL1, BCR

Biomarker Type: Rearrangement

Present: True

Rearrangement Type: Fusion


Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Organization(s) Biomarker(s) Cancer type Therapy(ies)
EMA (5) FDA (1) HSE (3) BCR::ABL1, CD19 + Acute Lymphoid Leukemia Blinatumomab
EMA (1) HSE (1) BCR::ABL1, CD22 + Acute Lymphoid Leukemia Inotuzumab ozogamicin
EMA (2) BCR::ABL1 Chronic Myelogenous Leukemia Imatinib
EMA (2) BCR::ABL1 Acute Lymphoid Leukemia Imatinib
EMA (1) HSE (1) BCR::ABL1 Acute Lymphoid Leukemia Ponatinib
EMA (1) HSE (1) ABL1 p.T315I, BCR::ABL1 Acute Lymphoid Leukemia Ponatinib
EMA (1) HSE (1) BCR::ABL1 Chronic Myelogenous Leukemia Asciminib
EMA (3) BCR::ABL1 Chronic Myelogenous Leukemia Dasatinib
EMA (2) BCR::ABL1 Acute Lymphoid Leukemia Dasatinib
EMA (3) BCR::ABL1 Chronic Myelogenous Leukemia Nilotinib
HSE (1) BCR::ABL1 Acute Lymphoid Leukemia Blinatumomab
FDA (2) BCR::ABL1 Chronic Myelogenous Leukemia Asciminib
FDA (1) ABL1 p.T315I, BCR::ABL1 Chronic Myelogenous Leukemia Asciminib
EMA (3) FDA (2) HSE (1) BCR::ABL1 Chronic Myelogenous Leukemia Bosutinib
FDA (3) BCR::ABL1 Chronic Myelogenous Leukemia Dasatinib
FDA (3) BCR::ABL1 Chronic Myeloid Leukemia, BCR-ABL1+ Dasatinib
FDA (2) BCR::ABL1 Acute Lymphoid Leukemia Dasatinib
FDA (2) BCR::ABL1 Chronic Myelogenous Leukemia Imatinib
EMA (2) FDA (2) BCR::ABL1 Chronic Myeloid Leukemia, BCR-ABL1+ Imatinib
FDA (2) BCR::ABL1 Acute Lymphoid Leukemia Imatinib
FDA (3) BCR::ABL1 Chronic Myelogenous Leukemia Nilotinib
FDA (3) BCR::ABL1 Chronic Myeloid Leukemia, BCR-ABL1+ Nilotinib
FDA (1) BCR::ABL1 Acute Lymphoid Leukemia Cytarabine, Methotrexate, Ponatinib, Prednisone, Vincristine
FDA (1) ABL1 p.T315I, BCR::ABL1 Acute Lymphoid Leukemia Ponatinib
FDA (2) BCR::ABL1 Chronic Myeloid Leukemia, BCR-ABL1+ Asciminib